In vitro cartilage degradation byescherichia coli andstaphylococcus aureus
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چکیده
منابع مشابه
Aggrecanases and cartilage matrix degradation
The loss of extracellular matrix macromolecules from the cartilage results in serious impairment of joint function. Metalloproteinases called 'aggrecanases' that cleave the Glu373-Ala374 bond of the aggrecan core protein play a key role in the early stages of cartilage destruction in rheumatoid arthritis and in osteoarthritis. Three members of the ADAMTS family of proteinases, ADAMTS-1, ADAMTS-...
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OBJECTIVE Using the alginate bead three-dimensional culturing method, which is considered to be advantageous for the in vitro study of chondrocytes, we confirmed earlier reports concerning the inhibitory effect of TGF-β on IL-1β-induced cartilage destruction and serially evaluated changes in proteinases and their inhibitors in cartilage destruction. METHODS Chondrocytes were cultured on algin...
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Introduction. Degradation of articular cartilage is a central feature of joint diseases. Proteolysis of the two major structural components of the extracellular matrix of articular cartilage, namely aggrecan and type II collagen, disrupts the mechanical integrity of the tissue leading eventually to erosion and exposure of subchondral bone. Depletion of aggrecan is one of the earliest events in ...
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Osteoarthritis, the most common joint disease, affecting millions people world-wide, involves the degradation of the articular cartilage which provides frictionless contact between the bones in a joint during movement. To a first approximation, this tissue is composed of two components, a collagen framework and entrapped proteoglycans. The framework consists of type II collagen fibrils built on...
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The present studies demonstrate that bacterial lipopolysaccharides (LPS) induce cartilage matrix degradation in live explants in organ culture. Quintuplicate bovine nasal fibrocartilage explants cultured for 8 d with three different purified LPS preparations derived from Escherichia coli and Salmonella typhosa at concentrations ranging from 1.0 to 25.0 micrograms/ml resulted in matrix proteogly...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1982
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780250413